Our team brings together exceptional talent with a passion to explore uncharted territory and a laser focus on bringing new medicines to patients — with a sense of urgency.
Grow your expertise on problems that matter.
At Pinnacle Medicines, you'll work closely with scientists across the full spectrum of drug discovery - from chemistry and biology to formulation and CMC.
We've deliberately built a culture without silos because breakthroughs often happen at the interfaces between disciplines. Program updates, data, and decisions are shared openly across the company, and everyone — regardless of seniority — is encouraged to contribute and push the science forward.
For early-career researchers, this means sitting at the table from day one with access to the raw data, candid conversations, and the experience of those who've successfully brought new medicines to patients.
Breakthrough science runs on rigor and curiosity in equal measure. At Pinnacle, both are valued.
We are building a multidisciplinary team of scientists, engineers, and drug development experts advancing next-generation peptide therapeutics. Explore opportunities to contribute to our growing discovery and development programs.
Lead structural biology strategy to unlock the molecular design of next-generation peptide therapeutics. Read more
About the Role
This role will be responsible for developing and executing forward-looking protein science, structural biology and biophysics strategy. The ideal candidate will have a deep understanding of the unique characteristics of peptides as a therapeutic modality and accordingly position biophysics and structural biology as a key differentiator of our discovery platform. The candidate will have a clear perspective on how structural biology can be integrated with traditional structure-based design and emerging AI-based methods. The candidate will be part of the core discovery teams and effectively integrate biophysics and structural biology at all stages from hit ID to LO.
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Lead cross-functional program strategy across Pinnacle's peptide discovery and development portfolio. Read more
About the Role
We are seeking a strategic and execution-focused Executive Director of Project Management to lead cross-functional program management across Pinnacle's peptide discovery and development portfolio. This individual will serve as a core member of the development leadership team and will be responsible for driving integrated program strategy, governance, timelines, and resource alignment from early discovery through IND-enabling activities and into early clinical development. The ideal candidate brings deep experience managing complex drug development programs in biotech environments and has demonstrated success aligning scientific, regulatory, CMC, and external partner functions to deliver milestone-driven outcomes. The position will be reporting to the Head of Translational Science.
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Lead pharmacokinetics and drug metabolism strategy across a growing peptide pipeline. Read more
About the Role
We are seeking a highly motivated and experienced Director of DMPK at our Doylestown, PA site. The candidate will work within the discovery team and be responsible for ADME/DMPK aspects of all of our peptide discovery and development pipeline, including lead identification/optimization, FIH translation, and non-clinical packages to support regulatory filings. The candidate must have demonstrated an ability to work collaboratively in a fast-paced, dynamic environment with excellent scientific and communication skills. The position will be reporting to the Head of Translational Science.
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Preferred Skills
Shape nonclinical safety strategy for next-generation peptide therapeutics. Read more
About the Role
We are seeking a strategic and scientifically rigorous Senior Director of Toxicology to lead nonclinical safety strategy across Pinnacle's peptide development portfolio. This role will be responsible for designing and executing toxicology programs to support IND-enabling studies, regulatory submissions, and early clinical development. The successful candidate will serve as the nonclinical safety lead on project teams and will work closely with DMPK, Bioanalytics, and Regulatory to ensure comprehensive and risk-mitigated development strategies. The position will be reporting to the Head of Translational Science.
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Preferred Skills
Lead bioanalytical strategy and execution across peptide discovery and development programs. Read more
About the Role
We are seeking a highly experienced Director of Bioanalytics to lead bioanalytical strategy and execution across Pinnacle's peptide discovery and development programs. This role will be responsible for establishing and overseeing bioanalytical platforms to support pharmacokinetics, toxicology, and translational studies from discovery through clinical development. The candidate will play a critical role in assay development, method validation, and regulatory-compliant bioanalysis to enable robust PK/PD characterization and regulatory submissions. The position will be reporting to the Head of Translational Science.
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Lead peptide chemistry strategy across discovery and early development programs. Read more
Job Summary
We are seeking a highly motivated and experienced Director of Chemistry at our Doylestown, PA (on site). The successful candidate will work within the discovery and early development teams and be responsible for leading process chemistry of our peptide programs. The candidate must have demonstrated an ability to work collaboratively in a fast-paced, multidisciplinary, dynamic environment with excellent scientific and communication skills.
Key Responsibilities
Qualifications
We are growing and continuously seeking outstanding talent. If you do not see an open role that fits your background today, please email hr@pinnaclemedicines.com and share how you could help us build a leading peptide discovery company.